Bukatar magungunan warkewa
COVID-19 yana haifar da kamuwa da cuta tare da sabon labari na SARS-CoV-2 pathogen, wanda ke shiga kuma yana shiga sel mai masauki ta hanyar furotin mai girma.A halin yanzu, akwai sama da miliyan 138.3 da aka rubuta a duniya, yayin da adadin wadanda suka mutu ya kusan miliyan uku.
Ko da yake an amince da allurar rigakafin don amfani da gaggawa, an yi tambaya game da tasirinsu akan wasu sabbin bambance-bambancen.Haka kuma, allurar rigakafin aƙalla kashi 70% na al'umma a duk ƙasashen duniya na iya ɗaukar lokaci mai tsawo, idan aka yi la'akari da saurin rigakafin da ake yi a yanzu, ƙarancin samar da allurar rigakafi, da ƙalubalen dabaru.
Duniya har yanzu za ta buƙaci ingantattun magunguna masu aminci, don haka, don shiga cikin mummunan rashin lafiya da wannan ƙwayar cuta ta haifar.Binciken na yanzu yana mai da hankali kan mutum ɗaya da ayyukan haɗin gwiwa na curcumin da nanostructures akan ƙwayar cuta.

Bukatar magungunan warkewa
COVID-19 yana haifar da kamuwa da cuta tare da sabon labari na SARS-CoV-2 pathogen, wanda ke shiga kuma yana shiga sel mai masauki ta hanyar furotin mai girma.A halin yanzu, akwai sama da miliyan 138.3 da aka rubuta a duniya, yayin da adadin wadanda suka mutu ya kusan miliyan uku.
Ko da yake an amince da allurar rigakafin don amfani da gaggawa, an yi tambaya game da tasirinsu akan wasu sabbin bambance-bambancen.Haka kuma, allurar rigakafin aƙalla kashi 70% na al'umma a duk ƙasashen duniya na iya ɗaukar lokaci mai tsawo, idan aka yi la'akari da saurin rigakafin da ake yi a yanzu, ƙarancin samar da allurar rigakafi, da ƙalubalen dabaru.
Duniya har yanzu za ta buƙaci ingantattun magunguna masu aminci, don haka, don shiga cikin mummunan rashin lafiya da wannan ƙwayar cuta ta haifar.Binciken na yanzu yana mai da hankali kan mutum ɗaya da ayyukan haɗin gwiwa na curcumin da nanostructures akan ƙwayar cuta.

Curcumin
Curcumin wani fili ne na polyphenolic wanda ke ware daga rhizome na shukar turmeric, Curcuma longa.Ya ƙunshi manyan curcuminoid a cikin wannan shuka, a 77% na jimlar, yayin da ƙaramin fili curcumin II ya zama 17%, kuma curcumin III ya ƙunshi 3%.
An kwatanta Curcumin kuma an yi nazari sosai, a matsayin kwayoyin halitta tare da kayan magani.An yi rikodin haƙuri da amincin sa da kyau, tare da matsakaicin adadin 12 g / rana.
An kwatanta amfani da shi azaman anti-mai kumburi, anticancer, da antioxidant, da kuma antiviral.An ba da shawarar Curcumin azaman kwayar halitta mai yuwuwar warkar da edema na huhu da sauran matakai masu rauni waɗanda ke haifar da fibrosis na huhu bayan COVID-19.

Curcumin yana hana enzymes na kwayar cuta
Ana tsammanin hakan ya faru ne saboda iyawarta na hana kwayar cutar kanta, da kuma daidaita hanyoyin kumburi.Yana daidaita rubutun hoto da ka'idoji, yana ɗaure tare da babban ƙarfi ga babban ƙwayar cuta mai ƙwayar cuta (Mpro) enzyme wanda shine mabuɗin don kwafi kuma yana hana haɗin haɗin hoto da shigarwa cikin tantanin halitta.Hakanan yana iya rushe tsarin ƙwayoyin cuta.
Abubuwan da ke gaba da cutar sun haɗa da cutar hanta ta C, ƙwayar cuta ta rigakafi ta mutum (HIV), cutar Epstein-Barr da cutar mura A.An ba da rahoton hana 3C-kamar protease (3CLpro) yadda ya kamata fiye da sauran samfuran halitta, gami da quercetin, ko magunguna kamar chloroquine da hydroxychloroquine.
Wannan na iya ba da damar rage nauyin ƙwayoyin cuta a cikin tantanin halitta da sauri fiye da sauran magungunan da ba a hana su ba, kuma don haka hana kamuwa da cuta zuwa matsanancin ciwo na numfashi (ARDS).
Hakanan yana hana protease mai kama da papain (PLpro) tare da 50% inhibitory maida hankali (IC50) na 5.7 µM wanda ya wuce quercetin da sauran samfuran halitta.

Curcumin yana hana mai karɓar mai karɓa
Kwayar cutar tana haɗawa da mai karɓar mai karɓar tantanin halitta, angiotensin-mai canza enzyme 2 (ACE2).Nazarin samfuri ya nuna cewa curcumin yana hana wannan hulɗar mai karɓar ƙwayoyin cuta ta hanyoyi biyu, ta hanyar hana duka furotin mai karu da mai karɓar ACE2.
Duk da haka, curcumin yana da ƙananan bioavailability, saboda ba ya narke da kyau a cikin ruwa kuma ba shi da kwanciyar hankali a cikin kafofin watsa labaru na ruwa, musamman a mafi girma pH.Lokacin da aka gudanar da shi ta baki, yana fuskantar saurin metabolism ta hanji da hanta.Ana iya shawo kan wannan cikas ta amfani da nanosystems.
Ana iya amfani da masu ɗaukar nanostructured da yawa don wannan dalili, kamar nanoemulsions, microemulsions, nanogels, micelles, nanoparticles da liposomes.Irin waɗannan masu ɗaukar hoto suna hana rushewar metabolism na curcumin, yana ƙaruwa da ƙarfi kuma yana taimaka masa ta motsa ta cikin membranes na halitta.
Kayayyakin curcumin na tushen nanostructure uku ko fiye sun riga sun kasance na kasuwanci, amma kaɗan nazarce sun gwada ingancinsu akan COVID-19 a vivo.Wadannan sun nuna iyawar abubuwan da aka tsara don daidaita matakan rigakafi da kuma rage alamun cutar, kuma watakila suna gaggauta farfadowa.